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Learn about treatment options for moderate to severe painful intercourse due to menopause

About Premarin® (conjugated estrogens) Vaginal Cream

To treat moderate to severe painful intercourse due to menopause.

What To Expect From Treatment

 

How Premarin Vaginal Cream works.

For many menopausal women, changes to the vagina can cause pain during intercourse, called dyspareunia.

Premarin Vaginal Cream is clinically proven to relieve moderate to severe painful intercourse caused by menopausal changes. It works by delivering estrogens directly to the source of the pain, which helps rebuild vaginal tissue and make intercourse more comfortable.

Sticking with your treatment plan is key to feeling relief. In a 12-week clinical study, just 0.5 g of Premarin Vaginal Cream twice a week significantly relieved moderate to severe painful intercourse due to menopause. Individual results may vary.

Premarin Vaginal Cream should be used at the lowest effective dose for the shortest duration consistent with the treatment goals and risks for the individual woman.

Illustration of vaginal wall cells

Illustrative image after treatmentIllustrative image before treatment

This image is for illustrative purposes only.

 
BEFORE TREATMENT
AFTER TREATMENT

Slide to see before 12 weeks of treatment

Slide to see after 12 weeks of treatment

How It Works

Take a closer look at how Premarin Vaginal Cream works in the body to help rebuild vaginal walls.

Now that you know how it works, start the conversation with your doctor. Our videos can help.

VIDEO LIBRARY

Help staying on track with treatment.

To treat moderate to severe painful intercourse, a symptom of vulvar and vaginal atrophy (VVA) due to menopause, Premarin Vaginal Cream can be applied twice a week or in a cyclic regimen of 21 days of therapy, followed by 7 days off therapy, using a 0.5 g dose.

To treat VVA, Premarin Vaginal Cream should be applied in a cyclic regimen of 21 days on therapy, followed by 7 days off therapy. Generally, women should be started at the 0.5 g dosage strength. Dosage adjustments (0.5 to 2 g) may be made based on individual response.

To help you remember to apply your prescribed dose, you could set reminders.

Estrogens should be used at the lowest effective dose, for the shortest duration consistent with treatment goals and risks for the individual woman. You and your doctor should talk regularly to decide how long you need treatment.

Set reminder on phone to help stay on track with postmenopausal moderate to severe painful intercourse treatment
Learn about what to expect from treatment with PREMARIN® (conjugated estrogens) Vaginal Cream. See risks and benefits.
PREMARIN® (conjugated estrogens) Vaginal Cream | Safety Info

How To Apply Premarin Vaginal Cream

How to Apply

Step-by-step instructions on how to apply Premarin Vaginal Cream. Learn about applicator use.

There’s more. Check out other videos about Premarin Vaginal Cream.

VIDEO LIBRARY  

Instructions for Use.

How to apply treatment for moderate to severe painful intercourse due to menopausal changes

STEP ONE

Remove cap from tube.

Applying treatment for moderate to severe painful intercourse due to menopausal changes

STEP TWO

Screw nozzle end of applicator onto tube.

Step-by-step instructions to apply treatment for moderate to severe painful intercourse due to menopausal changes

STEP THREE

Gently squeeze the tube from the bottom to force sufficient cream into the barrel to provide the prescribed dose.

Use the marked stopping points on the applicator to measure the correct dose, as prescribed by your healthcare provider.

Instructions to apply moderate to severe painful intercourse treatment due to menopause

STEP FOUR

Unscrew applicator from tube.

How to use applicator to apply moderate to severe painful intercourse treatment due to menopause

STEP FIVE

Lie on back with knees drawn up. To deliver medication, gently insert applicator deeply into vagina and press plunger downward to its original position.

How to clean moderate to severe painful intercourse treatment applicator after use

STEP SIX

TO CLEANSE: Pull plunger to remove it from barrel. Wash with mild soap and warm water.

DO NOT BOIL OR USE HOT WATER.

Frequently Asked Questions




Learn how to apply PREMARIN® (conjugated estrogens) Vaginal Cream by watching a video and downloading step-by-step instructions. See risks and benefits.
PREMARIN® (conjugated estrogens) Vaginal Cream | Safety Info

Ordering Free Replacement Applicators

The tools you need to help you stick with your treatment plan.

Your free replacement order will include 10 Premarin Vaginal Cream applicators and will arrive in 2-3 weeks. Do not throw away your applicator until you receive your replacement applicators. Talk to your doctor regularly and attend follow-up appointments to discuss length of treatment.

Estrogens used with or without progestins should be used at the lowest effective dose for the shortest duration consistent with treatment goals and risks for the individual woman.

1-866-298-8486.

Call to order free applicators.

Order free PREMARIN® (conjugated estrogens) Vaginal Cream applicators. See risks and benefits.
PREMARIN® (conjugated estrogens) Vaginal Cream | Safety Info

Possible Side Effects

Learn about the possible side effects associated with PREMARIN® (conjugated estrogens) Vaginal Cream. See risks and benefits.
PREMARIN® (conjugated estrogens) Vaginal Cream | Safety Info