X

You are now leaving PREMARINVAGINALCREAM.com

You are now leaving the PREMARINVAGINALCREAM.com website. Links to other websites are provided as a convenience to the viewer. Pfizer accepts no responsiblity for the content of linked sites.

BACK

About Premarin Vaginal Cream

To treat moderate to severe painful intercourse due to menopause.

How It Works

Why Premarin Vaginal Cream?

After menopause, changes to the vagina can cause pain during intercourse, called dyspareunia.

Premarin Vaginal Cream is clinically proven to relieve moderate to severe painful intercourse caused by menopausal changes. Unlike over-the-counter treatments, it works by delivering estrogens directly to the source of the pain, to help rebuild vaginal tissue and make intercourse more comfortable.

With Premarin Vaginal Cream, you’re not taking a hormone pill. It’s a hormone-based cream applied vaginally. You simply apply a blueberry-sized dose with a special applicator directly to the affected area.

LEARN MORE

In a 12-week clinical study, just 0.5 g of Premarin Vaginal Cream twice a week significantly relieved moderate to severe painful intercourse due to menopause. Individual results may vary.

Premarin Vaginal Cream should be used at the lowest effective dose for the shortest duration consistent with the treatment goals and risks for the individual woman.

Illustration of vaginal wall cells

Illustrative image after treatmentIllustrative image before treatment

This image is for illustrative purposes only.

BEFORE TREATMENT
AFTER TREATMENT

Slide to see before 12 weeks of treatment

Slide to see after 12 weeks of treatment

How It Helps

Watch the video to take a closer look at how Premarin Vaginal Cream works in the body to help rebuild vaginal walls.

Now that you know how it works, start the conversation with your doctor. Our discussion guide can help.

DOWNLOAD DISCUSSION GUIDE

Dosing Information for Painful Intercourse

To treat moderate to severe painful intercourse, a symptom of vulvar and vaginal atrophy (VVA) due to menopause, Premarin Vaginal Cream can be applied twice a week or in a cyclic regimen of 21 days of therapy, followed by 7 days off therapy, using a 0.5 g dose.

To help you remember to apply your prescribed dose, you could set reminders.

Estrogens should be used at the lowest effective dose, for the shortest duration consistent with treatment goals and risks for the individual woman. You and your doctor should talk regularly to decide how long you need treatment.

Set reminder on phone to help stay on track with postmenopausal moderate to severe painful intercourse treatment

How To Apply Premarin Vaginal Cream

How to Apply

Step-by-step instructions on how to apply Premarin Vaginal Cream. Learn about applicator use.

There’s more. Check out other videos about Premarin Vaginal Cream.

VIDEO LIBRARY

Instructions for Use.

How to apply treatment for moderate to severe painful intercourse due to menopausal changes

STEP ONE

Remove cap from tube.

Applying treatment for moderate to severe painful intercourse due to menopausal changes

STEP TWO

Screw nozzle end of applicator onto tube.

Step-by-step instructions to apply treatment for moderate to severe painful intercourse due to menopausal changes

STEP THREE

Gently squeeze the tube from the bottom to force sufficient cream into the barrel to provide the prescribed dose.

Use the marked stopping points on the applicator to measure the correct dose, as prescribed by your healthcare provider.

Instructions to apply moderate to severe painful intercourse treatment due to menopause

STEP FOUR

Unscrew applicator from tube.

How to use applicator to apply moderate to severe painful intercourse treatment due to menopause

STEP FIVE

Lie on back with knees drawn up. To deliver medication, gently insert applicator deeply into vagina and press plunger downward to its original position.

How to clean moderate to severe painful intercourse treatment applicator after use

STEP SIX

TO CLEANSE: Pull plunger to remove it from barrel. Wash with mild soap and warm water.

DO NOT BOIL OR USE HOT WATER.

STEP ONE 1

How to apply treatment for moderate to severe painful intercourse due to menopausal changes

STEP ONE

Remove cap from tube.

STEP TWO 2

Applying treatment for moderate to severe painful intercourse due to menopausal changes

STEP TWO

Screw nozzle end of applicator onto tube.

STEP THREE 3

Step-by-step instructions to apply treatment for moderate to severe painful intercourse due to menopausal changes

STEP THREE

Gently squeeze the tube from the bottom to force sufficient cream into the barrel to provide the prescribed dose.

Use the marked stopping points on the applicator to measure the correct dose, as prescribed by your healthcare provider.

STEP FOUR 4

Instructions to apply moderate to severe painful intercourse treatment due to menopause

STEP FOUR

Unscrew applicator from tube.

STEP FIVE 5

How to use applicator to apply moderate to severe painful intercourse treatment due to menopause

STEP FIVE

Lie on back with knees drawn up. To deliver medication, gently insert applicator deeply into vagina and press plunger downward to its original position.

STEP SIX 6

How to clean moderate to severe painful intercourse treatment applicator after use

STEP SIX

TO CLEANSE: Pull plunger to remove it from barrel. Wash with mild soap and warm water.

DO NOT BOIL OR USE HOT WATER.

Common Treatment Questions

How do I apply Premarin Vaginal Cream?

Premarin Vaginal Cream comes with its own applicator to help apply the cream directly. Premarin Vaginal Cream helps
treat vaginal changes due to menopause and moderate to severe painful intercourse caused by these changes.

  • The applicator is designed to help measure your prescribed dosage.
  • Premarin Vaginal Cream uses a non-liquefying base.

View full application instructions here.

How much should I use?

Your doctor will prescribe the dosage that’s right for you. Estrogens, with or without a progestin, should be used at the lowest effective dose for the shortest duration of time. A single tube of Premarin Vaginal Cream can last up to 6 months depending on the dose prescribed.

How often should I apply Premarin Vaginal Cream?

Apply Premarin Vaginal Cream as directed by your healthcare professional. With a variety of dosing options, your doctor can tailor your treatment to your needs. You and your healthcare professional should talk regularly to decide how long you need treatment.

  • To treat moderate to severe painful intercourse due to menopause, Premarin Vaginal Cream can be applied twice a week or in a cyclic regimen of 21 days on therapy, followed by 7 days off therapy, using a 0.5 g dose.
  • To treat vulvar and vaginal atrophy (VVA), Premarin Vaginal Cream should be applied in a cyclic regimen of 21 days on therapy, followed by 7 days off therapy. Generally, women should be started at the 0.5 g dosage strength. Dosage adjustments (0.5 to 2 g) may be made based on individual response.
  • You can apply the cream at any time of day that works for you in accordance with your prescribed treatment schedule. You may want to consider picking a time of day to apply Premarin Vaginal Cream and sticking to it. For example, on the twice-a-week regimen, you might choose Monday and Thursday evenings, right before bed.

How long until I start to feel a difference with painful intercourse?

In a clinical study, patients taking Premarin Vaginal Cream felt significant relief of moderate to severe painful intercourse due to menopause at 12 weeks. Individual results may vary.

Ordering Free Replacement Applicators

The tools to help you stick with your treatment plan.

Your free replacement order will include 10 Premarin Vaginal Cream applicators and will arrive in 2-3 weeks. Do not throw away your applicator until you receive your replacement applicators. Talk to your doctor regularly and attend follow-up appointments to discuss length of treatment.

Estrogens with or without progestins should be used at the lowest effective dose for the shortest duration consistent with treatment goals and risks for the individual woman.

1-866-298-8486.

Call to order free applicators.

See risks & benefits. Learn how to use PREMARIN® Vaginal Cream to treat moderate to severe painful intercourse due to menopause.
About PREMARIN® (conjugated estrogens) Vaginal Cream | Safety Info

Possible Side Effects

See risks & benefits. Learn how to use PREMARIN® Vaginal Cream to treat moderate to severe painful intercourse due to menopause.
About PREMARIN® (conjugated estrogens) Vaginal Cream | Safety Info