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  • Full Prescribing Information, including BOXED WARNING and Patient Information
  • (En Español)
  • Important Safety Information
  • Indication

    Indication

    Premarin (conjugated estrogens) Vaginal Cream is used after menopause to treat moderate to severe painful intercourse caused by menopausal changes in and around the vagina.

  • For Healthcare Professionals
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  • About Premarin Vaginal Cream
    • Why Premarin Vaginal Cream?
    • Getting Started
    • Possible Side Effects
  • Sex After Menopause
    • Stages of Menopause
    • About Painful Sex
    • Is Treatment Right for You?
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Why Premarin Vaginal Cream?

Premarin Vaginal Cream helps rebuild vaginal tissue and makes moderate to severe painful sex after menopause more comfortable.

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Save* on your Rx

If eligible, you can pay as little as $35 for your Premarin Vaginal Cream prescription. 

SAVINGS INFO
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Get free tools and tips to help with your treatment.

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*Eligibility required. Available to commercially insured patients only. State and federal beneficiaries and cash-paying patients not eligible. See full Terms and Conditions below.

 See full Terms and Conditions below.

IMPORTANT SAFETY INFORMATION AND INDICATION

Using estrogen alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using Premarin (conjugated estrogens) Vaginal Cream. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus. Your healthcare provider should check any unusual vaginal bleeding to find out the cause.

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia (decline in brain function).

Using estrogen alone may increase your chances of getting strokes or blood clots. Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.

Using estrogens, with or without progestins, may increase your chance of getting dementia, based on a study of women 65 years of age or older.

Estrogens should be used at the lowest dose possible, only for as long as needed. You and your healthcare provider should talk regularly about whether you still need treatment.

Premarin Vaginal Cream should not be used if you have unusual vaginal bleeding, have, or had cancer, had a stroke or heart attack, have or had blood clots or liver problems, have a bleeding disorder, are allergic to any of its ingredients, or think you may be pregnant. In general, the addition of a progestin is recommended for women with a uterus to reduce the chance of getting cancer of the uterus.

If you take thyroid medication, consult your healthcare provider, as use of estrogens may change the amount needed.

Serious, but less common side effects include heart attack, stroke, blood clots, dementia, breast cancer, cancer of the lining of the uterus, cancer of the ovary, high blood pressure, high blood sugar, gallbladder disease, liver problems, enlargement of benign tumors of the uterus (fibroids), and severe allergic reaction.

Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you: new breast lumps; unusual vaginal bleeding; changes in vision or speech; sudden new severe headaches; severe pains in your chest or legs with or without shortness of breath, weakness and fatigue; swollen lips, tongue, and face.

Less serious, but common side effects include headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps/bloating, nausea and vomiting, hair loss, fluid retention, vaginal yeast infection, reactions from Premarin Vaginal Cream such as vaginal burning, irritation, and itching.

INDICATION

Premarin (conjugated estrogens) Vaginal Cream is used after menopause to treat moderate to severe painful intercourse caused by menopausal changes in and around the vagina.

Please see full Prescribing Information, including BOXED WARNING and Patient Information.

IMPORTANT SAFETY INFORMATION AND INDICATION

Using estrogen alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using Premarin (conjugated estrogens) Vaginal Cream. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus. Your healthcare provider should check any unusual vaginal bleeding to find out the cause.

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia (decline in brain function).

Using estrogen alone may increase your chances of getting strokes or blood clots. Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.

Using estrogens, with or without progestins, may increase your chance of getting dementia, based on a study of women 65 years of age or older.

Estrogens should be used at the lowest dose possible, only for as long as needed. You and your healthcare provider should talk regularly about whether you still need treatment.

Premarin Vaginal Cream should not be used if you have unusual vaginal bleeding, have, or had cancer, had a stroke or heart attack, have or had blood clots or liver problems, have a bleeding disorder, are allergic to any of its ingredients, or think you may be pregnant. In general, the addition of a progestin is recommended for women with a uterus to reduce the chance of getting cancer of the uterus.

If you take thyroid medication, consult your healthcare provider, as use of estrogens may change the amount needed.

Serious, but less common side effects include heart attack, stroke, blood clots, dementia, breast cancer, cancer of the lining of the uterus, cancer of the ovary, high blood pressure, high blood sugar, gallbladder disease, liver problems, enlargement of benign tumors of the uterus (fibroids), and severe allergic reaction.

Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you: new breast lumps; unusual vaginal bleeding; changes in vision or speech; sudden new severe headaches; severe pains in your chest or legs with or without shortness of breath, weakness and fatigue; swollen lips, tongue, and face.

Less serious, but common side effects include headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps/bloating, nausea and vomiting, hair loss, fluid retention, vaginal yeast infection, reactions from Premarin Vaginal Cream such as vaginal burning, irritation, and itching.

INDICATION

Premarin (conjugated estrogens) Vaginal Cream is used after menopause to treat moderate to severe painful intercourse caused by menopausal changes in and around the vagina.

Please see full Prescribing Information, including BOXED WARNING and Patient Information.

Terms & Conditions

By using this Pay As Little As $35 Savings Card, you acknowledge that you currently meet the eligibility criteria and will comply with the Terms and Conditions below:

  • Patients are not eligible to use this Card if they are enrolled in a state or federally funded insurance program, including but not limited to Medicaid, Medicare, TRICARE, Veterans Affairs health care, a state prescription drug assistance program, or the Government Health Insurance Plan available in Puerto Rico (formerly known as “La Reforma de Salud”).
  • Patient must have private insurance. Offer is not valid for cash-paying patients. The value of this Savings Card is limited to $150 per use or the amount of your co-pay, whichever is less. Limit 2 offers per calendar year. Maximum savings of $300 per calendar year.
  • This Savings Card is not valid when the entire cost of your prescription drug is eligible to be reimbursed by your private insurance plan or other private health or pharmacy benefit programs.
  • You must deduct the value of this Savings Card from any reimbursement request submitted to your private insurance plan, either directly by you or on your behalf.
  • You are responsible for reporting use of the Savings Card to any private insurer, health plan, or other third party who pays for or reimburses any part of the prescription filled using the Savings Card, as may be required. You should not use the Savings Card if your insurer or health plan prohibits use of manufacturer Savings Cards.
  • You must be 18 years of age or older to redeem the Savings Card.
  • This Savings Card is not valid where prohibited by law.
  • Savings Card cannot be combined with any other savings, free trial, or similar offer for the specified prescription.
  • Savings Card will be accepted only at participating pharmacies.
  • This Savings Card is not health insurance.
  • Offer good only in the U.S. and Puerto Rico.
  • Savings Card is limited to 1 per person during this offering period and is not transferable.
  • No other purchase is necessary.
  • Data related to your redemption of the Savings Card may be collected, analyzed, and shared with Pfizer, for market research and other purposes related to assessing Pfizer’s programs. Data shared with Pfizer will be aggregated and de-identified; it will be combined with data related to other Savings Card redemptions and will not identify you.
  • Pfizer reserves the right to rescind, revoke, or amend this offer without notice.
  • Offer expires 12/31/2023.

For reimbursement when using a nonparticipating pharmacy or a mail-order service:

  • Pay for Premarin® (conjugated estrogens) Vaginal Cream as you normally would.
  • Mail a copy of original pharmacy receipt (cash register receipt NOT valid) with product name, date, and amount paid circled to:

    Premarin Vaginal Cream Savings Card
    2250 Perimeter Park Drive, Suite 300
    Morrisville, NC 27560

Be sure to include a copy of the front of your Savings Card, your name, and your mailing address.

Visit www.PremarinVaginalCream.com for more information about Premarin Vaginal Cream. For help with the Savings Card, call 1-866-879-4600 or write to: Premarin Vaginal Cream Savings Card, 2250 Perimeter Park Drive, Suite 300, Morrisville, NC 27560. Be sure to include your name and mailing address.

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  • TERMS OF USE
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Patients should always ask their doctors for medical advice about adverse events.
You are encouraged to report an adverse event related to Pfizer products by calling 1-800-438-1985 (US only). If you prefer, you may contact the US Food and Drug Administration (FDA) directly.

The FDA has established a reporting service known as MedWatch where healthcare professionals and consumers can report serious problems they suspect may be associated with the drugs and medical devices they prescribe, dispense, or use. Visit MedWatch or call 1-800-FDA-1088.
The product information provided in this site is intended for residents of the United States. The products discussed herein may have different product labeling in different countries.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

© 2022 Pfizer Inc.
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June 2022
PP-PVC-USA-0849
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