Using estrogen-alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using Premarin (conjugated estrogens) Vaginal Cream. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
Do not use estrogens, with or without progestins, to prevent heart disease, heart attacks, strokes or dementia (decline in brain function).
Using estrogen-alone may increase your chances of getting strokes or blood clots. Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.
Using estrogens, with or without progestins, may increase your chance of getting dementia, based on a study of women 65 years of age or older.
Estrogens should be used at the lowest dose possible, only for as long as needed. You and your healthcare provider should talk regularly about whether you still need treatment.
Premarin (conjugated estrogens) Vaginal Cream should not be used if you have unusual vaginal bleeding, have or had cancer, had a stroke or heart attack, have or had blood clots or liver problems, have a bleeding disorder, are allergic to any of its ingredients, or think you may be pregnant.
Estrogens increase the risk of gallbladder disease. Discontinue estrogen if loss of vision, pancreatitis, or liver problems occur. If you take thyroid medication, consult your healthcare provider, as use of estrogens may change the amount needed.
Common side effects include headache, pelvic pain, breast pain, vaginal bleeding and vaginitis.
Premarin (conjugated estrogens) Vaginal Cream is used after menopause to treat menopausal changes in and around the vagina and to treat moderate to severe painful intercourse caused by these changes.
Please see Full Prescribing Information including BOXED WARNING and Patient Information.
Patients should always ask their doctors for medical advice about adverse events.
You may report an adverse event related to Pfizer products by calling 1-800-438-1985 (U.S. only). If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly. The FDA has established a reporting service known as MedWatch where healthcare professionals and consumers can report serious problems they suspect may be associated with the drugs and medical devices they prescribe, dispense, or use. Visit MedWatch or call 1-800-FDA-1088.
Pfizer, Attn: Premarin, 235 East 42nd Street, NY, NY 10017, www.pfizer.com
The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.
The product information and the Nurse Chat service provided on this site is intended only for residents of the United States. The products discussed herein may have different product labeling in different countries. The Nurse Chat is serviced by third-party entities, not Pfizer employees. Pfizer is not collecting or storing personal information from any individuals.
Terms & Conditions
By participating in the PREMARIN® (conjugated estrogens) Vaginal Cream Pay No More Than $15 Co-pay Card program, you acknowledge that you currently meet the eligibility criteria and will comply with the terms and conditions described below:
For reimbursement when using a nonparticipating pharmacy/mail order:
Premarin Vaginal Cream Co-pay Card
14001 Weston Parkway, Suite 103, Cary, NC 27513
Be sure to include a copy of the front of your $15 Co-pay Card, your name, and mailing address.