Are you experiencing vaginal dryness and/or painful sex after menopause?

Talk to your health care professional about whether PREMARIN Vaginal Cream might be right for you.

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Ask your health care professional about a cream that helps relieve and restore.

Prescribing Information for PREMARIN Vaginal Cream

Get the full Prescribing Information, including Boxed Warning, for PREMARIN Vaginal Cream.
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Important Safety Information

What is the most important information you should know about PREMARIN Vaginal Cream
(an estrogen mixture)?

  • Estrogens may increase the chance of getting cancer of the uterus.

Report any unusual vaginal bleeding right away while you are using PREMARIN Vaginal Cream. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your health care professional should check any unusual vaginal bleeding to find out the cause.

  • Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia.

Using estrogens, with or without progestins, may increase your chance of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogens, with or without progestins, may increase your chance of getting dementia, based on a study of women age 65 years or older. You and your health care professional should talk regularly about whether you still need treatment with PREMARIN Vaginal Cream.

  • PREMARIN Vaginal Cream is used after menopause to treat menopausal changes in and around the vagina and to treat painful intercourse caused by menopausal changes of the vagina.
  • PREMARIN Vaginal Cream should not be used if you have unusual vaginal bleeding, have or had cancer of the breast or uterus, had a stroke or heart attack, have or had blood clots or liver problems, are allergic to any of the ingredients in PREMARIN Vaginal Cream, or think you may be pregnant.
  • The most commonly reported side effects of PREMARIN Vaginal Cream include headache, infection, abdominal pain, back pain, accidental injury, and vaginitis.