Are you experiencing vaginal dryness and/or painful sex after menopause?

Talk to your health care professional about whether PREMARIN Vaginal Cream might be right for you.

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PREMARIN Vaginal Cream addresses the underlying cause of vaginal symptoms associated with menopause.

What Is PREMARIN Vaginal Cream?

PREMARIN Vaginal Cream is a proven therapy with a low-dose option that can help reverse the menopausal changes in the vagina that can cause bothersome symptoms, like vaginal dryness and painful sex.

PREMARIN Vaginal Cream treats the underlying cause of these symptoms, and can restore the vaginal tissues that provide elasticity and lubrication.

PREMARIN Vaginal Cream is a proven treatment option that:

  • Addresses the underlying cause of vaginal symptoms associated with menopause, including vaginal dryness and painful sex
  • Reverses changes in the vagina after menopause to help relieve bothersome symptoms
  • Can help maintain the reversal of vaginal changes with continued use
  • Offers low-dose options that can be tailored to meet your needs

How PREMARIN Vaginal Cream Works


  • PREMARIN Vaginal Cream works to treat vaginal discomfort and painful sex by delivering a blend of estrogens directly to the tissues in and around your vagina.
  • PREMARIN Vaginal Cream doesn't mask symptoms for temporary relief. PREMARIN Vaginal Cream addresses the cause of vaginal dryness and painful sex at its source — treating the estrogen loss that causes this common menopausal symptom. Apply PREMARIN Vaginal Cream as directed by your health care professional.
  • PREMARIN Vaginal Cream can reverse vaginal thinning and dryness and restore vaginal tissue — tissue that provides elasticity and lubrication. And with continued use, you can maintain this reversal.

PREMARIN Vaginal Cream: What to Expect

How much cream will you need?

PREMARIN Vaginal Cream is available in a variety of doses
(0.5 g to 2.0 g), so your doctor or health care professional can tailor treatment to your individual needs.

When do you apply the cream?

Apply PREMARIN Vaginal Cream as directed by your health care professional.

What are the possible side effects of PREMARIN Vaginal Cream?

The most commonly reported side effects of PREMARIN Vaginal Cream include headache, infection, abdominal pain, back pain, accidental injury, and vaginitis.

Who should not use PREMARIN Vaginal Cream?

Do not start using PREMARIN Vaginal Cream if you have unusual vaginal bleeding; currently have or have had certain cancers (Estrogens may increase the chance of getting certain types of cancers, including cancer of the breast or uterus. If you have or have had cancer, talk with your health care professional about whether you should use PREMARIN Vaginal Cream.); had a stroke or heart attack; currently have or have had blood clots; currently have or have had liver problems; are allergic to PREMARIN Vaginal Cream or any of its ingredients (See the Prescribing Information for a list of ingredients); or think you may be pregnant.

How long does it take to work?

In clinical studies, women using PREMARIN Vaginal Cream experienced relief from vaginal discomfort and painful sex within 3-4 weeks.

Where is it applied?

PREMARIN Vaginal Cream can be applied directly to vaginal tissues — for relief wherever your symptoms are most bothersome. And its formulation is designed to not liquefy.

How is it applied?

The Gentle Measure® Applicator is designed to help you measure your prescribed dosage neatly and precisely. Learn more about Applying PREMARIN Vaginal Cream.

Note: It's important to remember that PREMARIN Vaginal Cream is not approved for treating other menopausal symptoms, such as hot flashes. If you are experiencing hot flashes and night sweats, or are concerned about postmenopausal osteoporosis (bone loss), ask your health care professional about other treatments that are available for these conditions.

Gentle Measure is a registered trademark of Wyeth Pharmaceuticals Inc.

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Important Safety Information

What is the most important information I should know about PREMARIN Vaginal Cream
(an estrogen mixture)?

  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb)
  • Report any unusual vaginal bleeding right away while you are using PREMARIN Vaginal Cream. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find the cause
  • Do not use estrogen-alone to prevent heart disease, heart attacks, strokes or dementia (decline in brain function)
  • Using estrogen-alone may increase your chances of getting strokes or blood clots
  • Do not use estrogens with progestins to prevent heart disease, heart attacks, or dementia
  • Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots
  • Using estrogens with progestins may increase your chance of getting dementia, based on a study of women age 65 years or older
  • You and your healthcare provider should talk regularly about whether you still need treatment with PREMARIN Vaginal Cream

PREMARIN® Vaginal Cream is used after menopause to treat menopausal changes in and around the vagina and painful intercourse caused by these changes.

It should not be used if you have unusual vaginal bleeding, have or had cancer of the breast or uterus, had a stroke or heart attack, have or had blood clots or liver problems, are allergic to any of its ingredients, or think you may be pregnant.

Most common side effects include headache, infection, abdominal pain, back pain, accidental injury, and vaginitis.

Please see Patient Information. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088