Premarin Vaginal Cream comes with its own applicator that helps you apply it directly to your vaginal tissue. The applicator is designed to help you measure your prescribed dosage neatly and precisely and should be comfortable and easy to use.
Step 1
- Wash hands thoroughly
- Insert the applicator plunger into the smooth end (the end without grooves) of the applicator barrel (applicator will be pre-assembled the first time you use it)
- Remove cap from tube
- Screw the tube onto the grooved end of the applicator
Step 2
- Gently squeeze tube from the bottom until cream fills the applicator up to the measurement mark corresponding to the dose your doctor prescribed
- Be careful to fill the applicator with cream only up to the level of your prescribed dose
- Unscrew and remove the applicator from the tube
Step 3
- Lie on your back with your knees drawn up
- Gently insert the applicator deep into the vagina
- Push the plunger in all the way to fully dispense the cream
- Remove the applicator from the vagina
Premarin Vaginal Cream is used in and around the vagina, so you can apply it right where you feel the discomfort.
Cleaning and storing the applicator
- After use, remove the plunger from the barrel of the applicator
- Wash both parts of the applicator in warm, soapy water to remove all traces of cream (DO NOT PLACE IN DISHWASHER OR USE HOT OR BOILING WATER)
- Rinse the applicator and allow it to dry; store it in a safe, convenient place
Note: Latex or rubber condoms, diaphragms, and cervical caps may be weakened and fail when they come into contact with Premarin Vaginal Cream.
Important Safety Information
What is the most important information I should know about PREMARIN Vaginal Cream (an estrogen mixture)?
- Using estrogen-alone may increase your chance of getting cancer of the uterus (womb)
- Report any unusual vaginal bleeding right away while you are using PREMARIN Vaginal Cream. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find the cause
- Do not use estrogen-alone to prevent heart disease, heart attacks, strokes or dementia (decline in brain function)
- Using estrogen-alone may increase your chances of getting strokes or blood clots
- Do not use estrogens with progestins to prevent heart disease, heart attacks, or dementia
- Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots
- Using estrogens with progestins may increase your chance of getting dementia, based on a study of women age 65 years or older
- You and your healthcare provider should talk regularly about whether you still need treatment with PREMARIN Vaginal Cream
PREMARIN® Vaginal Cream is used after menopause to treat menopausal changes in and around the vagina and painful intercourse caused by these changes.
It should not be used if you have unusual vaginal bleeding, have or had cancer of the breast or uterus, had a stroke or heart attack, have or had blood clots or liver problems, are allergic to any of its ingredients, or think you may be pregnant.
Most common side effects include headache, infection, abdominal pain, back pain, accidental injury, and vaginitis.
Please see Patient Information. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call
1-800-FDA-1088.