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Wyeth Pharmaceuticals
P.O. Box 8299
Philadelphia, PA 19101-8299

If you have any questions or would like additional information, please call Wyeth Pharmaceuticals at 1-800-934-5556.

Important Safety Information

What is the most important information you should know about PREMARIN Vaginal Cream (a cream of estrogens)?

Estrogens increase the chances of getting cancer of the uterus.

Report any unusual vaginal bleeding right away while you are using PREMARIN Vaginal Cream. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your health care provider should check any unusual vaginal bleeding to find out the cause.
Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia.
Using estrogens with or without progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogens, with or without progestins, may increase your risk of dementia, based on a study of women age 65 years or older. You and your health care provider should talk regularly about whether you still need treatment with PREMARIN Vaginal Cream.

PREMARIN^® (conjugated estrogens) Vaginal Cream is used after menopause to treat dryness, itching, and burning, in and around the vagina.
The most commonly reported side effects of PREMARIN Vaginal Cream include vaginal discomfort or pain, breast pain, vaginitis, and itching.
PREMARIN Vaginal Cream should not be used if you have unusual vaginal bleeding, have or had cancer of the breast or uterus, had a stroke or heart attack in the past year, have or had blood clots, have liver problems, are allergic to any of the ingredients in PREMARIN Vaginal Cream, or think you may be pregnant.