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Premarin Vaginal Cream is proven to help relieve painful intercourse due to menopause.

What is Premarin Vaginal Cream?

Premarin Vaginal Cream is a proven treatment for changes in the vaginal tissue after menopause that can cause painful intercourse and dryness. It is a topical estrogen cream that has been prescribed for over 65 years.

While using it, Premarin Vaginal Cream helps:

  • Reverse vaginal thinning and dryness
  • Restore your natural ability to create your own lubrication
  • Relieve painful intercourse due to menopause when used just twice weekly

When used as prescribed, Premarin Vaginal Cream allows you to maintain this reversal and vaginal tissue improvement. That's something no over-the-counter product was designed to do. And with a variety of dosing options, your doctor can tailor your treatment to your needs.

How Premarin Vaginal Cream works

Premarin Vaginal Cream treats painful intercourse after menopause by delivering a blend of estrogens directly to the tissues in and around your vagina — where it's needed most. Because it is a topical treatment, it's able to treat the underlying cause of painful intercourse right at its source.

When used just twice a week, Premarin Vaginal Cream restores vaginal tissue that provides the lubrication you're missing, so intercourse can be more comfortable. Apply Premarin Vaginal Cream as directed by your health care professional.

Each gram contains 0.625mg of conjugated estrogen USP.

Important Safety Information
What is the most important information I should know about PREMARIN Vaginal Cream (an estrogen mixture)?

  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb)
  • Report any unusual vaginal bleeding right away while you are using PREMARIN Vaginal Cream. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find the cause
  • Do not use estrogen-alone to prevent heart disease, heart attacks, strokes or dementia (decline in brain function)
  • Using estrogen-alone may increase your chances of getting strokes or blood clots
  • Do not use estrogens with progestins to prevent heart disease, heart attacks, or dementia
  • Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots
  • Using estrogens with progestins may increase your chance of getting dementia, based on a study of women age 65 years or older
  • You and your healthcare provider should talk regularly about whether you still need treatment with PREMARIN Vaginal Cream

PREMARIN® Vaginal Cream is used after menopause to treat menopausal changes in and around the vagina and painful intercourse caused by these changes.

It should not be used if you have unusual vaginal bleeding, have or had cancer of the breast or uterus, had a stroke or heart attack, have or had blood clots or liver problems, are allergic to any of its ingredients, or think you may be pregnant.

Most common side effects include headache, infection, abdominal pain, back pain, accidental injury, and vaginitis.

Please see Patient Information. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call
1-800-FDA-1088.

Ask your doctor if Premarin Vaginal Cream is right for you

Understanding
Painful Intercouse
After Menopause

For many women, intercourse becomes painful after menopause because of changes in the vaginal tissue. Learn more about painful intercourse after menopause

Do You Have
Vaginal Atrophy?

Take our quick Vaginal Symptoms Self-Assessment to help you evaluate your symptoms.